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Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046.
Li, Jiao; Wang, Yujia; Hao, Xiaomeng; Li, Shasha; Jia, Jia; Guan, Yan; Peng, Zonggen; Bi, Hongkai; Xiao, Chunling; Cen, Shan; Gan, Maoluo.
Affiliation
  • Li J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Wang Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Hao X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Li S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Jia J; Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China.
  • Guan Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Peng Z; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Bi H; Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China.
  • Xiao C; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Cen S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Gan M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. ganml@imb.pumc.edu.cn.
Molecules ; 24(15)2019 Aug 02.
Article in En | MEDLINE | ID: mdl-31382398
ABSTRACT
A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3ß-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC50 values ranging from 0.5 to 7.7 µM. Compounds 1 and 2 showed antibacterial activities against Helicobacter pylori, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1-16 µg/mL.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Penicillium / Biological Products / Aquatic Organisms Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Penicillium / Biological Products / Aquatic Organisms Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Document type: Article Affiliation country: China