MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway.

Wang, Zhe; Liang, Xue Ya; Chang, Xin; Nie, Yao Yan; Guo, Chen; Jiang, Jin Hong; Chang, Min

Wang, Zhe; Liang, Xue Ya; Chang, Xin; Nie, Yao Yan; Guo, Chen; Jiang, Jin Hong; Chang, Min.

Affiliation

Wang Z; School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shanxi 710061, China.
Liang XY; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Chang X; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Nie YY; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Guo C; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Jiang JH; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Chang M; Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.

Molecules ; 24(15)2019 Aug 03.

Article in En | MEDLINE | ID: mdl-31382637

Subject(s)

Anti-Inflammatory Agents/pharmacology; Intracellular Signaling Peptides and Proteins/metabolism; Peptides/pharmacology; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/metabolism; Signal Transduction/drug effects; Animals; Apoptosis/drug effects; Colitis/drug therapy; Colitis/etiology; Colitis/metabolism; Cytokines/metabolism; Dextran Sulfate/adverse effects; Inflammation Mediators/metabolism; Mice; NF-kappa B/metabolism; Phosphorylation

Key words

MAPK-activated protein kinase II (MK2); MMI-0100; apoptosis; dextran sodium sulfate (DSS); inflammatory bowel disease (IBD)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Signal Transduction / Protein Serine-Threonine Kinases / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors / Anti-Inflammatory Agents Type of study: Etiology_studies Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Document type: Article Affiliation country: China

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