Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment.

Jezek, Jan; Chang, Kai-Ti; Joshi, Amogh M; Strich, Randy

Jezek, Jan; Chang, Kai-Ti; Joshi, Amogh M; Strich, Randy.

Affiliation

Jezek J; Graduate School of Biomedical Sciences, Two Medical Center Drive, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.
Chang KT; Graduate School of Biomedical Sciences, Two Medical Center Drive, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.
Joshi AM; School of Osteopathic Medicine, One Medical Center Drive, Rowan University, Stratford, NJ, USA.
Strich R; Graduate School of Biomedical Sciences, Two Medical Center Drive, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

EMBO Rep ; 20(9): e47425, 2019 09.

Article in En | MEDLINE | ID: mdl-31385392

Subject(s)

Cyclin C/metabolism; Mitochondria/metabolism; bcl-2-Associated X Protein/metabolism; Animals; Apoptosis/physiology; Blotting, Western; Cell Line; Fluorescent Antibody Technique; HeLa Cells; Humans; Immunoprecipitation; Mice; Mice, Knockout; Mitochondrial Membranes/metabolism; Protein Transport/physiology; Signal Transduction/physiology

Key words

Bcl-2 homology; Cdk8; apoptosis; cyclin C; mitochondria

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bcl-2-Associated X Protein / Cyclin C / Mitochondria Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EMBO Rep Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom

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