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Trans-acting non-synonymous variant of FOXA1 predisposes to hepatocellular carcinoma through modulating FOXA1-ERα transcriptional program and may have undergone natural selection.
Wang, Sheng; Xiang, Chan; Mou, Lin; Yang, Yuan; Zhong, Rong; Wang, Liyan; Sun, Chang; Qin, Zhaoyu; Yang, Jingmin; Qian, Ji; Zhao, Yuanyuan; Wang, Yi; Pan, Xuedong; Qie, Jingbo; Jiang, Yan; Wang, Xiaofeng; Yang, Yajun; Zhou, Wei-Ping; Miao, Xiaoping; He, Fuchu; Jin, Li; Wang, Haijian.
Affiliation
  • Wang S; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Xiang C; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Mou L; Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Yang Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhong R; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
  • Wang L; Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health (Incubation), Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), School of Public Health, Tongji Medical Col
  • Sun C; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Qin Z; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Yang J; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Qian J; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhao Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang Y; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
  • Pan X; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Qie J; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Jiang Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang X; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Yang Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhou WP; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Miao X; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
  • He F; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Jin L; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
  • Wang H; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Carcinogenesis ; 41(2): 146-158, 2020 04 22.
Article in En | MEDLINE | ID: mdl-31400761
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / Carcinoma, Hepatocellular / Genetic Predisposition to Disease / Estrogen Receptor alpha / Hepatocyte Nuclear Factor 3-alpha / Liver Neoplasms Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Carcinogenesis Year: 2020 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / Carcinoma, Hepatocellular / Genetic Predisposition to Disease / Estrogen Receptor alpha / Hepatocyte Nuclear Factor 3-alpha / Liver Neoplasms Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Carcinogenesis Year: 2020 Document type: Article Affiliation country: China Country of publication: United kingdom