Ceftriaxone Dosing in a Critically Ill Patient With Hypoalbuminemia During Continuous Venous Hemofiltration: Emphasis on Unbound Pharmacokinetics.

Ebisch, Renée M F; Meenks, Sjoerd D; Foudraine, Norbert; Janssen, Paddy K C; le Noble, Jos L M L

Ebisch, Renée M F; Meenks, Sjoerd D; Foudraine, Norbert; Janssen, Paddy K C; le Noble, Jos L M L.

Affiliation

Ebisch RMF; Department of Intensive Care, VieCuri Medical Center Venlo, Venlo, the Netherlands.
Meenks SD; Department of Hospital Pharmacy, VieCuri Medical Center Venlo, Venlo, the Netherlands.
Foudraine N; Department of Clinical Pharmacy and Toxicology, CAPHRI School of Public Health and Primary Care, Maastricht University Medical Center, Maastricht, the Netherlands.
Janssen PKC; Department of Intensive Care, VieCuri Medical Center Venlo, Venlo, the Netherlands.
le Noble JLML; Department of Hospital Pharmacy, VieCuri Medical Center Venlo, Venlo, the Netherlands.

J Clin Pharmacol ; 60(1): 140-142, 2020 01.

Article in En | MEDLINE | ID: mdl-31407809

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Ceftriaxone/pharmacokinetics; Escherichia coli Infections/drug therapy; Hypoalbuminemia/complications; Shock, Septic/therapy; Aged; Anti-Bacterial Agents/therapeutic use; Ceftriaxone/therapeutic use; Critical Illness; Escherichia coli Infections/complications; Escherichia coli Infections/metabolism; Female; Hemofiltration; Humans; Shock, Septic/complications

Key words

ceftriaxone; continuous venovenous hemofiltration; hypoalbuminemia; pharmacokinetics; unbound plasma concentration

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shock, Septic / Ceftriaxone / Hypoalbuminemia / Escherichia coli Infections / Anti-Bacterial Agents Limits: Aged / Female / Humans Language: En Journal: J Clin Pharmacol Year: 2020 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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