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Risk of Zika microcephaly correlates with features of maternal antibodies.
Robbiani, Davide F; Olsen, Priscilla C; Costa, Federico; Wang, Qiao; Oliveira, Thiago Y; Nery, Nivison; Aromolaran, Adeolu; do Rosário, Mateus S; Sacramento, Gielson A; Cruz, Jaqueline S; Khouri, Ricardo; Wunder, Elsio A; Mattos, Adriana; de Paula Freitas, Bruno; Sarno, Manoel; Archanjo, Gracinda; Daltro, Dina; Carvalho, Gustavo B S; Pimentel, Kleber; de Siqueira, Isadora C; de Almeida, João R M; Henriques, Daniele F; Lima, Juliana A; Vasconcelos, Pedro F C; Schaefer-Babajew, Dennis; Azzopardi, Stephanie A; Bozzacco, Leonia; Gazumyan, Anna; Belfort, Rubens; Alcântara, Ana P; Carvalho, Gustavo; Moreira, Licia; Araujo, Katiaci; Reis, Mitermayer G; Keesler, Rebekah I; Coffey, Lark L; Tisoncik-Go, Jennifer; Gale, Michael; Rajagopal, Lakshmi; Adams Waldorf, Kristina M; Dudley, Dawn M; Simmons, Heather A; Mejia, Andres; O'Connor, David H; Steinbach, Rosemary J; Haese, Nicole; Smith, Jessica; Lewis, Anne; Colgin, Lois; Roberts, Victoria.
Affiliation
  • Robbiani DF; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY drobbiani@rockefeller.edu.
  • Olsen PC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Costa F; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Wang Q; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
  • Oliveira TY; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
  • Nery N; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Aromolaran A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • do Rosário MS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
  • Sacramento GA; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
  • Cruz JS; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • Khouri R; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
  • Wunder EA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
  • Mattos A; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
  • de Paula Freitas B; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
  • Sarno M; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • Archanjo G; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • Daltro D; Universidade Federal de São Paulo, São Paulo, Brazil.
  • Carvalho GBS; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
  • Pimentel K; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • de Siqueira IC; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • de Almeida JRM; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • Henriques DF; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
  • Lima JA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
  • Vasconcelos PFC; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
  • Schaefer-Babajew D; Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
  • Azzopardi SA; Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
  • Bozzacco L; Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Belfort R; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
  • Alcântara AP; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
  • Carvalho G; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Moreira L; Universidade Federal de São Paulo, São Paulo, Brazil.
  • Araujo K; Hospital Santo Amaro, Salvador, Bahia, Brazil.
  • Reis MG; Hospital Santo Amaro, Salvador, Bahia, Brazil.
  • Keesler RI; Hospital Santo Amaro, Salvador, Bahia, Brazil.
  • Coffey LL; Hospital Aliança, Salvador, Bahia, Brazil.
  • Tisoncik-Go J; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
  • Gale M; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
  • Rajagopal L; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
  • Adams Waldorf KM; California National Primate Research Center, University of California, Davis, Davis, CA.
  • Dudley DM; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.
  • Simmons HA; Washington National Primate Research Center, Seattle, WA.
  • Mejia A; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.
  • O'Connor DH; Department of Immunology, University of Washington, Seattle, WA.
  • Steinbach RJ; Washington National Primate Research Center, Seattle, WA.
  • Haese N; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.
  • Smith J; Department of Immunology, University of Washington, Seattle, WA.
  • Lewis A; Department of Global Health, University of Washington, Seattle, WA.
  • Colgin L; Department of Global Health, University of Washington, Seattle, WA.
  • Roberts V; Department of Pediatrics, University of Washington, Seattle, WA.
J Exp Med ; 216(10): 2302-2315, 2019 10 07.
Article in En | MEDLINE | ID: mdl-31413072
ABSTRACT
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Zika Virus / Zika Virus Infection / Maternal-Fetal Exchange / Microcephaly / Antibodies, Viral Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: J Exp Med Year: 2019 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Zika Virus / Zika Virus Infection / Maternal-Fetal Exchange / Microcephaly / Antibodies, Viral Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: J Exp Med Year: 2019 Document type: Article