Overview of Urethral Reconstruction by Tissue Engineering: Current Strategies, Clinical Status and Future Direction.
Tissue Eng Regen Med
; 16(4): 365-384, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31413941
ABSTRACT
BACKGROUND:
Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral dilation and urethrotomy; but in cases of long urethral strictures, substitution urethroplasty with genital skin and buccal mucosa grafts is the only option. However a number of complications such as infection as a result of hair growth in neo-urethra, and stone formation restrict the application of those grafts. Therefore, tissue engineering techniques recently emerged as an alternative approach, aiming to overcome those restrictions. The aim of this review is to provide a comprehensive coverage on the strategies employed and the translational status of urethral tissue engineering over the past years and to propose a combinatory strategy for the future of urethral tissue engineering.METHODs:
Data collection was based on the key articles published in English language in years between 2006 and 2018 using the searching terms of urethral stricture and tissue engineering on PubMed database.RESULTS:
Differentiation of mesenchymal stem cells into urothelial and smooth muscle cells to be used for urologic application does not offer any advantage over autologous urothelial and smooth muscle cells. Among studied scaffolds, synthetic scaffolds with proper porosity and mechanical strength is the best option to be used for urethral tissue engineering.CONCLUSION:
Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a pre-vascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urologic Surgical Procedures, Male
/
Urethra
/
Plastic Surgery Procedures
/
Tissue Engineering
Limits:
Animals
/
Humans
Language:
En
Journal:
Tissue Eng Regen Med
Year:
2019
Document type:
Article
Affiliation country:
Malaysia