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Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium.
Liang, Xiao; Matthew, Susan; Chen, Qi-Yin; Kwan, Jason C; Paul, Valerie J; Luesch, Hendrik.
Affiliation
  • Liang X; Department of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
  • Matthew S; Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , Gainesville , Florida 32610 , United States.
  • Chen QY; Department of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
  • Kwan JC; Department of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
  • Paul VJ; Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , Gainesville , Florida 32610 , United States.
  • Luesch H; Department of Medicinal Chemistry , University of Florida , Gainesville , Florida 32610 , United States.
Org Lett ; 21(18): 7274-7278, 2019 09 20.
Article in En | MEDLINE | ID: mdl-31414826
Quorum sensing (QS) plays a critical role in the regulation of bacterial pathogenesis. Doscadenamide A (1a) was isolated from a marine cyanobacterium, its structure elucidated by NMR, and its activity linked to QS induction. The total synthesis of 1a was developed, and the absolute configuration confirmed through comparison of the isolated natural product with synthetic diastereomers. Our preliminary investigation indicated that 1a could activate QS signaling in a LasR-dependent manner.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pyrroles / Cyanobacteria / Drug Discovery / Anti-Bacterial Agents Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pyrroles / Cyanobacteria / Drug Discovery / Anti-Bacterial Agents Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States