Exploration of supersaturable lacidipine ternary amorphous solid dispersion for enhanced dissolution and in vivo absorption.

Guan, Jian; Jin, Liwei; Liu, Qiaoyu; Xu, Huan; Wu, Haiyang; Zhang, Xin; Mao, Shirui

Guan, Jian; Jin, Liwei; Liu, Qiaoyu; Xu, Huan; Wu, Haiyang; Zhang, Xin; Mao, Shirui.

Affiliation

Guan J; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jin L; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Q; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xu H; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wu H; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang X; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Mao S; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: maoshirui@syphu.edu.cn.

Eur J Pharm Sci ; 139: 105043, 2019 Nov 01.

Article in En | MEDLINE | ID: mdl-31415903

Subject(s)

Dihydropyridines/administration & dosage; Drug Carriers/administration & dosage; Excipients/administration & dosage; Polyethylene Glycols/administration & dosage; Polyvinyls/administration & dosage; Sodium Dodecyl Sulfate/administration & dosage; Surface-Active Agents/administration & dosage; Animals; Biological Availability; Dihydropyridines/chemistry; Dihydropyridines/pharmacokinetics; Drug Carriers/chemistry; Drug Carriers/pharmacokinetics; Drug Liberation; Drug Stability; Excipients/chemistry; Excipients/pharmacokinetics; Intestinal Absorption/drug effects; Polyethylene Glycols/chemistry; Polyethylene Glycols/pharmacokinetics; Polyvinyls/chemistry; Polyvinyls/pharmacokinetics; Rats, Sprague-Dawley; Sodium Dodecyl Sulfate/chemistry; Sodium Dodecyl Sulfate/pharmacokinetics; Surface-Active Agents/chemistry; Surface-Active Agents/pharmacokinetics

Key words

Amorphous solid dispersion; Lacidipine; Pharmacodynamics; SDS; Soluplus; Stability

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Polyvinyls / Sodium Dodecyl Sulfate / Surface-Active Agents / Dihydropyridines / Drug Carriers / Excipients Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2019 Document type: Article Affiliation country: China Country of publication: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google