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Switching Off Cancer-Causing Telomerase Using Small Molecules.
Asamitsu, Sefan; Shioda, Norifumi; Sugiyama, Hiroshi.
Affiliation
  • Asamitsu S; Department of Genomic Neurology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 8600811, Japan.
  • Shioda N; Department of Genomic Neurology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 8600811, Japan.
  • Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 6068502, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 6068501, Japan. Electronic address: hs@kuchem.kyoto-u.ac.jp.
Cell Chem Biol ; 26(8): 1045-1047, 2019 08 15.
Article in En | MEDLINE | ID: mdl-31419416
Aberrant telomerase activity via the expression of its catalytic subunit hTERT is a hallmark of some malignant cancers. In this issue of Cell Chemical Biology, Song et al. (2019) demonstrate that hTERT downregulation by targeting a repressive DNA motif on the gene promoter using small molecules effectively kills cancer cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomerase / G-Quadruplexes / Neoplasms Limits: Humans Language: En Journal: Cell Chem Biol Year: 2019 Document type: Article Affiliation country: Japan Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomerase / G-Quadruplexes / Neoplasms Limits: Humans Language: En Journal: Cell Chem Biol Year: 2019 Document type: Article Affiliation country: Japan Country of publication: United States