The effect of uric acid on sleep quality after acute ischemic stroke.
J Clin Neurosci
; 69: 155-159, 2019 Nov.
Article
in En
| MEDLINE
| ID: mdl-31420274
ABSTRACT
Sleep disturbance is a common psychiatric complication after stroke. Oxidative stress has been an important pathophysiological mechanism of sleep disturbance. However, no study has explored the relationship between uric acid (UA) and post-stroke sleep quality. This prospective study included 191 patients who were followed up for two months after acute ischemic stroke. Serum UA levels were measured at admission and divided into 3 tertiles (≤251⯵mol/L, 252-326⯵mol/L, ≥327⯵mol/L). Patients in the 3rd tertile of UA levels had a lower incidence of poor sleep quality than those belonging to 2nd or 1st tertile, respectively (9.7% vs. 27.7% vs. 35.9%; Pâ¯=â¯0.002). Furthermore, high UA levels (≥327⯵mol/L) were independently associated with low risk of poor sleep quality (ORâ¯=â¯0.129, 95%CIâ¯=â¯0.031-0.528, Pâ¯=â¯0.004) after adjusting for demographics, cardiovascular risk factors, stroke severity, functional outcome and depressive symptoms. High modified Rankin Scale score and depressive symptoms were associated with increased risk of poor sleep quality after stroke (ORâ¯=â¯1.836, 95%CIâ¯=â¯1.035-3.354, Pâ¯=â¯0.038) and (ORâ¯=â¯5.082, 95%CIâ¯=â¯1.709-15.115, Pâ¯=â¯0.003). In conclusion, high UA levels may reduce the risk of poor sleep quality after acute ischemic stroke. Further randomized controlled trials are necessary in examining whether appropriate UA supplement could provide a potential prevention or therapeutic target for sleep disturbance after stroke.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep Wake Disorders
/
Uric Acid
/
Stroke
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Clin Neurosci
Journal subject:
NEUROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
China