AMPK: Potential Therapeutic Target for Alzheimer's Disease.
Curr Protein Pept Sci
; 21(1): 66-77, 2020.
Article
in En
| MEDLINE
| ID: mdl-31424367
ABSTRACT
Alzheimer's disease (AD) is the most common neurodegenerative disorder. The pathogenesis of AD is very complicated. For decades, the amyloid hypothesis has influenced and guided research in the field of AD. Meanwhile, researchers gradually realized that AD is caused by multiple concomitant factors, such as autophagy, mitochondrial quality control, insulin resistance and oxidative stress. In current clinical trials, the improvement strategies of AD, such as Aß antibody immunotherapy and gamma secretase inhibitors, are limited. There is mounting evidence of neurodegenerative disorders indicated that activation of AMP-activated protein kinase (AMPK) may have broad neuroprotective effects. We reviewed the researches on AMPK for AD, the results demonstrated that activation of AMPK is controversial in Aß deposition and tau phosphorylation, but is positive to promote autophagy, maintain mitochondrial quality control, reduce insulin resistance and relieve oxidative stress. It is concluded that AMPK might be a new target for AD by aggressively treating the risk factors in the future.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrones
/
Ribonucleotides
/
Thiophenes
/
Amyloid beta-Peptides
/
Tau Proteins
/
Neuroprotective Agents
/
AMP-Activated Protein Kinases
/
Alzheimer Disease
/
Aminoimidazole Carboxamide
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Curr Protein Pept Sci
Journal subject:
BIOQUIMICA
Year:
2020
Document type:
Article
Affiliation country:
China