Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation To Maintain Proteostasis and Extracellular Matrix Production.

Zhang, Jing; Jamaluddin, Mohammad; Zhang, Yueqing; Widen, Steven G; Sun, Hong; Brasier, Allan R; Zhao, Yingxin

Zhang, Jing; Jamaluddin, Mohammad; Zhang, Yueqing; Widen, Steven G; Sun, Hong; Brasier, Allan R; Zhao, Yingxin.

Affiliation

Brasier AR; Institute for Clinical and Translational Research , University of Wisconsin-Madison School of Medicine and Public Health , Madison , Wisconsin 53705 , United States.

J Proteome Res ; 18(9): 3447-3460, 2019 09 06.

Article in En | MEDLINE | ID: mdl-31424945

Subject(s)

Airway Remodeling/genetics; Endoribonucleases/genetics; Lung Injury/genetics; Protein Serine-Threonine Kinases/genetics; X-Box Binding Protein 1/genetics; Epithelial Cells/metabolism; Epithelial Cells/pathology; Epithelial-Mesenchymal Transition/genetics; Extracellular Matrix/genetics; Extracellular Matrix/pathology; Extracellular Matrix Proteins/genetics; Glycosylation; Hexosamines/genetics; Hexosamines/metabolism; Humans; Lung Injury/metabolism; Lung Injury/pathology; Proteostasis/genetics; Signal Transduction/genetics

Key words

N-glycosylation; and hexosamine biosynthesis pathway; epithelial-mesenchymal transition; extracellular matrix; proteomics; secretome; unfolded protein response

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Endoribonucleases / Lung Injury / Airway Remodeling / X-Box Binding Protein 1 Limits: Humans Language: En Journal: J Proteome Res Journal subject: BIOQUIMICA Year: 2019 Document type: Article Country of publication: United States

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