Catalytic Enantioselective House-Meinwald Rearrangement: Efficient Construction of All-Carbon Quaternary Stereocenters.
J Am Chem Soc
; 141(35): 13783-13787, 2019 09 04.
Article
in En
| MEDLINE
| ID: mdl-31429560
ABSTRACT
A catalytic asymmetric House-Meinwald rearrangement for the synthesis of both cyclic and acyclic ketones is disclosed. From readily accessible racemic tetrasubstituted epoxides, this approach provides efficient access to chiral ketones bearing α all-carbon quaternary stereocenters with high enantiocontrol. The observation of positive nonlinear effects and nontrivial kinetic feature provided important insights into the mechanism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Am Chem Soc
Year:
2019
Document type:
Article
Affiliation country:
China