Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response.

Lucchetta, Marta; da Piedade, Isabelle; Mounir, Mohamed; Vabistsevits, Marina; Terkelsen, Thilde; Papaleo, Elena

Lucchetta, Marta; da Piedade, Isabelle; Mounir, Mohamed; Vabistsevits, Marina; Terkelsen, Thilde; Papaleo, Elena.

Affiliation

Lucchetta M; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
da Piedade I; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Mounir M; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Vabistsevits M; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Terkelsen T; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Papaleo E; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. elenap@cancer.dk.

BMC Cancer ; 19(1): 824, 2019 Aug 20.

Article in En | MEDLINE | ID: mdl-31429720

Subject(s)

Adenocarcinoma of Lung/genetics; Carcinoma, Squamous Cell/genetics; Lung Neoplasms/genetics; Membrane Glycoproteins/genetics; Mucin-5B/genetics; Mucins/genetics; Adenocarcinoma of Lung/immunology; Carcinoma, Squamous Cell/immunology; Cohort Studies; Databases, Nucleic Acid; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Interleukin-6/genetics; Keratins, Type I/genetics; Lung Neoplasms/immunology; Membrane Glycoproteins/metabolism; Mucin-5B/metabolism; Mucins/metabolism; Multigene Family/genetics; Proportional Hazards Models; RNA-Seq; Transcriptome; Tumor Microenvironment/immunology

Key words

Co-expression; Differential expression analysis; Lung adenocarcinoma; Lung squamous cell carcinoma; RNA-Seq; Soft clustering; Survival analysis; TCGA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Carcinoma, Squamous Cell / Mucin-5B / Adenocarcinoma of Lung / Lung Neoplasms / Mucins Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2019 Document type: Article Affiliation country: Denmark

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