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Urinary and plasmatic metabolomics strategy to explore the holistic mechanism of lignans in S. chinensis in treating Alzheimer's disease using UPLC-Q-TOF-MS.
Wei, Mengying; Liu, Zhongying; Liu, Yuanyuan; Li, Shizhe; Hu, Mingxin; Yue, Kexin; Liu, Tianshu; He, Yang; Pi, Zifeng; Liu, Zhiqiang; Song, Fengrui.
Affiliation
  • Wei M; State Key Laboratory of Electroanalytical Chemistry, National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. mslab21@ciac.ac.c
  • Liu Z; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. liuzy@jlu.edu.cn.
  • Liu Y; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. liuzy@jlu.edu.cn.
  • Li S; Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
  • Hu M; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. liuzy@jlu.edu.cn.
  • Yue K; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. liuzy@jlu.edu.cn.
  • Liu T; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. liuzy@jlu.edu.cn.
  • He Y; Department of Pharmaceutical Analysis, School of Pharmacy and Food Science, Zhuhai College of Jilin University, 8 Anji East Road, Zhuhai 519041, China.
  • Pi Z; State Key Laboratory of Electroanalytical Chemistry, National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. mslab21@ciac.ac.c
  • Liu Z; State Key Laboratory of Electroanalytical Chemistry, National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. mslab21@ciac.ac.c
  • Song F; State Key Laboratory of Electroanalytical Chemistry, National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. mslab21@ciac.ac.c
Food Funct ; 10(9): 5656-5668, 2019 Sep 01.
Article in En | MEDLINE | ID: mdl-31433414
ABSTRACT
Schisandra chinensis (Turcz.) Baill (S. chinensis), a functional food, is used as a tonic and sedative agent in traditional Chinese medicine. Modern pharmacological research has proved that S. chinensis could prevent and treat age-related neurodegenerative diseases. The presence of bioactive lignans in S. chinensis is the main reason for its neuroprotective and cognitive enhancement effects. This study aimed to clarify the mechanism of lignans in S. chinensis in ameliorating learning and memory deficits in Alzheimer's disease (AD) animals. The step-down test and Morris water maze (MWM) test were used to verify the effects of lignans in S. chinensis on learning and memory in AD animals. Then, metabolomics approaches based on ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) were used to clarify the mechanism of lignans in S. chinensis in treating AD. Finally, quantitative analysis of AD-related neurotransmitters in the brain was conducted after treatment with lignans in S. chinensis. In the MWM and step-down tests, lignans in S. chinensis showed a clear ability to ameliorate the impaired learning and memory of AD animals. A total of 31 endogenous metabolites were identified after treatment with lignans in S. chinensis, which were associated with lignans ameliorating learning and memory. These biomarkers were mainly associated with polyunsaturated fatty acid metabolism and amino acid and vitamin metabolism. Moreover, lignans in S. chinensis upregulated the levels of γ-aminobutyric acid (GABA), 5-hydroxytryptamine (5-HT), acetylcholine (Ach), norepinephrine (NE) and glycine (Gly) and downregulate the level of aspartic acid (Asp). Lignans in S. chinensis might alleviate the neurotoxic effects of neurological inflammation and oxidative stress, Aß deposition, and tau phosphorylation via the regulation of multiple endogenous metabolic pathways during pathological AD. The research might provide useful support for the further study of pharmacology and new drug development of lignans in S. chinensis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Lignans / Schisandra / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Food Funct Year: 2019 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Lignans / Schisandra / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Food Funct Year: 2019 Document type: Article Affiliation country: China