The characteristics of captopril challenge test-positive patients using various criteria.
J Renin Angiotensin Aldosterone Syst
; 20(3): 1470320319870891, 2019.
Article
in En
| MEDLINE
| ID: mdl-31434530
ABSTRACT
INTRODUCTION:
The captopril challenge test (CCT) is the major confirmatory test for primary aldosteronism (PA), and frequently carried out because of its convenience. However, it presents false-negative results with a certain probability, and as there are many criteria for CCT, it is not concluded yet which criteria to use. MATERIALS ANDMETHODS:
A total of 71 PA patients were evaluated. We compared CCT-positive and CCT-negative patients in the following three criteria plasma aldosterone/renin ratio (ARR) >200 after the CCT (criterion 1); plasma aldosterone concentration (PAC) >120 pg/ml after the CCT (criterion 2); and PAC suppression <30% of PAC before CCT (criterion 3).RESULTS:
The positive rate was 70.4%, 64.8% and 54.9% for criterion 1, criterion 2 and criterion 3, respectively. With criterion 1, the baseline plasma renin activity was lower, thus baseline ARR was higher in CCT-positive patients. With criterion 2, PAC was higher and estimated sodium intake and K were lower in CCT-positive patients. With criterion 3, K and PAC were lower in CCT-positive patients. Although it was not significant, in the patients with high sodium intake, the positive rate of criterion 1 was higher than that of the other criteria.CONCLUSIONS:
ARR>200 is the valuable criterion for the diagnosis of PA.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Captopril
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Renin Angiotensin Aldosterone Syst
Journal subject:
FISIOLOGIA
Year:
2019
Document type:
Article
Affiliation country:
Japan