Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells.
Chem Commun (Camb)
; 55(73): 10952-10955, 2019 Sep 10.
Article
in En
| MEDLINE
| ID: mdl-31441915
ABSTRACT
Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Azides
/
Acrylic Resins
/
Dinitrobenzenes
/
Hexosamines
/
Antibodies
Limits:
Animals
/
Humans
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2019
Document type:
Article
Affiliation country:
Belgium