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Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis.
Edrees, Mohammed Abdelssalam Hassan; Luo, Jiahui; Sun, Fei; Wang, Faxi; He, Long; Yue, Tiantian; Chen, Longmin; Zhang, Jing; Zhou, Haifeng; Yang, Chunliang; Yang, Ping; Xiong, Fei; Yu, Qilin; Adam, Bao-Ling; Liu, Furong; Li, Jinxiu; Zhang, Shu; Wang, Cong-Yi.
Affiliation
  • Edrees MAH; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Luo J; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Sun F; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Wang F; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • He L; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China; Department of Laboratory, Shanghai East Hospital, School of Medicine, Tongji University, 150 Ji Mo Road, Shanghai
  • Yue T; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Chen L; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Zhang J; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Zhou H; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Yang C; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Yang P; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Xiong F; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Yu Q; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  • Adam BL; Department of Surgery, Medical College of Georgia at Augusta University, 1120 15th Street, BI-4074, Augusta, GA 30912, USA.
  • Liu F; Department of Dermatology, the People's Hospital of Shishou City, Shishou, Hubei, China.
  • Li J; Shenzhen Third People's Hospital, 29 Bulan Road, Longgang District, Shenzhen, Guangdong 518000, China.
  • Zhang S; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China. Electronic address: szhang@tjh.tjmu.edu.cn.
  • Wang CY; The Center for Biomedical Research, the Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China. Electronic address: wangcy@tjh.tjmu.edu.
Mol Immunol ; 114: 314-322, 2019 10.
Article in En | MEDLINE | ID: mdl-31442915
ABSTRACT
Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that a conditional Ubc9 deletion in the hematopoietic system caused decreased thymus weight and reduced lymphocyte to myeloid cell ratio. Importantly, Ubc9 deletion in the hematopoietic system only selectively impaired the development of common lymphoid progenitors (CLPs) in the bone marrow and perturbed their potential to differentiate into lymphocytes, thereby decreasing the number of T/B cells in the periphery. Ubc9 was found to be required for CLP viability, and therefore, Ubc9 deficiency rendered CLPs to undergo apoptosis and attenuated their proliferation. Thus, Ubc9 plays a critical role in the regulation of CLP function during hematopoietic development in the bone marrow.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Hematopoietic Stem Cells / Ubiquitin-Conjugating Enzymes / Hematopoiesis Limits: Animals Language: En Journal: Mol Immunol Year: 2019 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Hematopoietic Stem Cells / Ubiquitin-Conjugating Enzymes / Hematopoiesis Limits: Animals Language: En Journal: Mol Immunol Year: 2019 Document type: Article Affiliation country: China