Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses.
Viruses
; 11(9)2019 08 22.
Article
in En
| MEDLINE
| ID: mdl-31443391
ABSTRACT
Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes a prime target for antiretroviral therapy. This activity, conserved among retroviruses and long terminal repeat (LTR) retrotransposons, involves a viral nucleoprotein complex called intasome. In the last decade, a plethora of structural insights on retroviral DNA integration arose from the study of FV. Here, we review the biochemistry and the structural features of the FV integration apparatus and will also discuss the mechanism of action of strand transfer inhibitors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Integration
/
Spumavirus
/
Integrases
Limits:
Animals
/
Humans
Language:
En
Journal:
Viruses
Year:
2019
Document type:
Article