Antimicrobial Treatment Provides a Competitive Advantage to Mycobacterium abscessus in a Dual-Species Biofilm with Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 63(11)2019 11.
Article
in En
| MEDLINE
| ID: mdl-31451500
ABSTRACT
The physiological factors that contribute to Mycobacterium abscessus lung infections remain unclear. We determined whether antibiotic treatment targeting a major cystic fibrosis pathogen (i.e., Pseudomonas aeruginosa) could provide the ideal conditions for the establishment of M. abscessus infection. Our data showed that P. aeruginosa inhibited M. abscessus biofilm formation under control conditions and that antimicrobial therapy selectively targeting P. aeruginosa diminished this competitive interaction, thereby increasing M. abscessus survival.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Biofilms
/
Mycobacterium abscessus
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2019
Document type:
Article
Affiliation country:
Spain