Alzheimer's Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin.
Curr Alzheimer Res
; 16(9): 834-835, 2019.
Article
in En
| MEDLINE
| ID: mdl-31453787
ABSTRACT
BACKGROUND:
Alzheimer's Disease (AD) features the accumulation of ß-amyloid in erythrocytes. The subsequent red cell damage may well affect their oxygen-carrying capabilities. 2,3- diphosphoglycerate (2,3-DPG) binds to the hemoglobin thereby promoting oxygen release. It is theorized that 2,3-DPG is reduced in AD and that the resulting hypoxia triggers erythropoietin (EPO) release. METHODS &OBJECTIVE:
To explore this theory, we analyzed red cell 2,3-DPG content and EPO in AD, mild cognitive impairment, and the control group, subjective cognitive impairment.RESULTS:
We studied (i) 2,3-DPG in red cells, and (ii) circulating EPO in AD, and both markers were unaffected by dementia. Disturbances of these oxygen-regulatory pathways do not appear to participate in brain hypoxia in AD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Erythropoietin
/
2,3-Diphosphoglycerate
/
Erythrocytes
/
Alzheimer Disease
/
Cognitive Dysfunction
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Curr Alzheimer Res
Journal subject:
NEUROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
Sweden