Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb.
Elife
; 82019 08 27.
Article
in En
| MEDLINE
| ID: mdl-31453803
ABSTRACT
Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Olfactory Bulb
/
Olfactory Receptor Neurons
/
Interneurons
/
Neural Pathways
Limits:
Animals
Language:
En
Journal:
Elife
Year:
2019
Document type:
Article
Affiliation country:
United States