A Novel Role for Triglyceride Metabolism in Foxp3 Expression.

Howie, Duncan; Ten Bokum, Annemieke; Cobbold, Stephen Paul; Yu, Zhanru; Kessler, Benedikt M; Waldmann, Herman

Howie, Duncan; Ten Bokum, Annemieke; Cobbold, Stephen Paul; Yu, Zhanru; Kessler, Benedikt M; Waldmann, Herman.

Affiliation

Howie D; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Ten Bokum A; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Cobbold SP; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Yu Z; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.
Kessler BM; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.
Waldmann H; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.

Front Immunol ; 10: 1860, 2019.

Article in En | MEDLINE | ID: mdl-31456800

Subject(s)

Forkhead Transcription Factors/genetics; T-Lymphocytes, Regulatory/metabolism; Triglycerides/metabolism; Animals; CD2 Antigens/genetics; CD52 Antigen/genetics; Cell Line; Diacylglycerol O-Acyltransferase/metabolism; Fatty Acids/metabolism; Female; Forkhead Transcription Factors/biosynthesis; Humans; Lipid Droplets/metabolism; Metabolome; Mice; Protein Kinase C/metabolism; T-Lymphocytes, Regulatory/enzymology; T-Lymphocytes, Regulatory/immunology

Key words

differentiation; lipotoxicity; metabolism; metabolomics; regulatory T (Treg) cell; tolerance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triglycerides / T-Lymphocytes, Regulatory / Forkhead Transcription Factors Limits: Animals / Female / Humans Language: En Journal: Front Immunol Year: 2019 Document type: Article Affiliation country: United kingdom Country of publication: Switzerland

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