Downregulated CHI3L1 alleviates skeletal muscle stem cell injury in a mouse model of sepsis.

Li, Fuxing; Sheng, Zhiyong; Lan, Haibing; Xu, Jianning; Li, Juxiang

Li, Fuxing; Sheng, Zhiyong; Lan, Haibing; Xu, Jianning; Li, Juxiang.

Affiliation

Li F; Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Sheng Z; Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Lan H; Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Xu J; Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Li J; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.

IUBMB Life ; 72(2): 214-225, 2020 02.

Article in En | MEDLINE | ID: mdl-31463997

Subject(s)

Cell Proliferation; Chitinase-3-Like Protein 1/antagonists & inhibitors; Disease Models, Animal; Inflammation/prevention & control; Muscle, Skeletal/cytology; Sepsis/prevention & control; Stem Cells/cytology; Animals; Cell Cycle; Chitinase-3-Like Protein 1/genetics; Chitinase-3-Like Protein 1/metabolism; Female; Inflammation/chemically induced; Inflammation/metabolism; Inflammation/pathology; Lipopolysaccharides/toxicity; Male; Mice; Muscle, Skeletal/injuries; Muscle, Skeletal/metabolism; RNA, Small Interfering; Sepsis/chemically induced; Sepsis/metabolism; Sepsis/pathology; Stem Cells/metabolism

Key words

CHI3L1; apoptosis; injury; proliferation; sepsis; skeletal muscle stem cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Sepsis / Muscle, Skeletal / Cell Proliferation / Disease Models, Animal / Chitinase-3-Like Protein 1 / Inflammation Limits: Animals Language: En Journal: IUBMB Life Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2020 Document type: Article Country of publication: United kingdom

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