Analysis of the Mechanisms of Action of Naphthoquinone-Based Anti-Acute Myeloid Leukemia Chemotherapeutics.

Lee, Michelle H; Lapidus, Rena G; Ferraris, Dana; Emadi, Ashkan

Lee, Michelle H; Lapidus, Rena G; Ferraris, Dana; Emadi, Ashkan.

Affiliation

Lee MH; Department of Medicine Division of Hematology/Oncology University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Lapidus RG; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA.
Ferraris D; Department of Medicine Division of Hematology/Oncology University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Emadi A; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA.

Molecules ; 24(17)2019 Aug 28.

Article in En | MEDLINE | ID: mdl-31466259

Subject(s)

Leukemia, Myeloid, Acute/metabolism; Naphthoquinones/pharmacology; Reactive Oxygen Species/metabolism; Cell Differentiation/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia, Myeloid, Acute/drug therapy; MAP Kinase Signaling System/drug effects; Membrane Potential, Mitochondrial/drug effects; Naphthoquinones/therapeutic use

Key words

acute myeloid leukemia (AML); apoptosis; mechanism of action; naphthoquinone; reactive oxygen species (ROS)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Naphthoquinones / Reactive Oxygen Species Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Document type: Article Affiliation country: United States Country of publication: Switzerland

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