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Stem Cell Composition of Umbilical Cord Blood Following Milking Compared with Delayed Clamping of the Cord Appears Better Suited for Promoting Hematopoiesis.
Katheria, Anup C; Amino, Ramina; Konop, Jason M; Orona, Anthony J; Kim, Elizabeth; Liu, Yang; Wu, Donlaong; Snyder, Evan Y.
Affiliation
  • Katheria AC; Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA. Electronic address: anup.katheria@sharp.com.
  • Amino R; Department of Pediatrics, University of California San Diego, La Jolla, CA; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
  • Konop JM; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
  • Orona AJ; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
  • Kim E; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
  • Liu Y; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
  • Wu D; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
  • Snyder EY; Department of Pediatrics, University of California San Diego, La Jolla, CA; Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA; Sanford Consortium for Regenerative Medicine, La Jolla, CA. Electronic address: esnyder@sbp.edu.
J Pediatr ; 216: 222-226, 2020 01.
Article in En | MEDLINE | ID: mdl-31471115
ABSTRACT
In comparing placental transfusion strategies, blood obtained from an umbilical cord that has been "milked" vs one in which clamping was simply delayed contains mesenchymal stromal cells in addition to solely hematopoietic stem cells, a composition more favorable for hematopoiesis, as suggested by its superior rescue of lethally irradiated bone marrow-depleted mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Blood Specimen Collection / Fetal Blood / Mesenchymal Stem Cells / Hematopoiesis Limits: Animals Language: En Journal: J Pediatr Year: 2020 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Blood Specimen Collection / Fetal Blood / Mesenchymal Stem Cells / Hematopoiesis Limits: Animals Language: En Journal: J Pediatr Year: 2020 Document type: Article