A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-Î³ signals.

Nakagawa, Masahiro Marshall; Rathinam, Chozha Vendan

Nakagawa, Masahiro Marshall; Rathinam, Chozha Vendan.

Affiliation

Nakagawa MM; Department of Genetics and Development, Columbia University Medical Center, 701W 168th street, New York, NY, 10032, USA.
Rathinam CV; Department of Genetics and Development, Columbia University Medical Center, 701W 168th street, New York, NY, 10032, USA. crathinam@ihv.umaryland.edu.

Sci Rep ; 9(1): 12658, 2019 09 02.

Article in En | MEDLINE | ID: mdl-31477755

Subject(s)

Hematopoietic Stem Cells/metabolism; Interferon-gamma/metabolism; Lymphopenia/metabolism; Signal Transduction; Animals; B-Lymphocytes/cytology; Cell Differentiation; Cell Lineage; Cell Proliferation; Erythroid Cells/metabolism; Erythroid Cells/pathology; Mice; T-Lymphocytes/cytology; Tumor Necrosis Factor alpha-Induced Protein 3/deficiency; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Signal Transduction / Interferon-gamma / Lymphopenia Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom

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