Breast-conserving surgery without radiation in elderly women with early breast cancer.
Surg Oncol
; 31: 22-25, 2019 Dec.
Article
in En
| MEDLINE
| ID: mdl-31479976
ABSTRACT
BACKGROUND AND OBJECTIVES:
Irradiation after breast-conserving surgery (BCS) decreases the incidence of ipsilateral breast tumor recurrence (IBTR) and breast cancer-related death. However, daily radiation treatments are burdensome to elderly patients, whose risk of IBTR is relatively low. Since 2001, we have offered BCS without radiation to patients meeting our selection criteria. This study assessed the prognosis of the patients who chose this option.METHODS:
Between 2001 and 2014, 203 patients met the selection criteria aged ≥60 years; pathologically node-negative, hormone-positive breast cancer; a negative surgical margin; and no lymphovascular invasion. Among these patients, 84 and 119 underwent BCS with or without radiation, respectively. IBTR, overall survival (OS), and breast cancer-specific survival (BCSS) were evaluated.RESULTS:
The median follow-up duration was 6.2 years. There were no significant differences in tumor size or the number of patients with adjuvant therapy between the groups. The 5-year IBTR rates were 0.9% and 1.6% in the non-irradiated and irradiated groups, respectively (pâ¯=â¯0.308). The 5-year OS rates were 94.1% and 98.7% (pâ¯=â¯0.391). Similarly, the 5-year BCSS rates were 97.2% and 98.7% (pâ¯=â¯0.812).CONCLUSION:
It is suggested that the omission of irradiation could be an option for elderly breast cancer patients who satisfy our criteria.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Mastectomy, Segmental
/
Carcinoma, Ductal, Breast
/
Radiotherapy, Adjuvant
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Surg Oncol
Journal subject:
NEOPLASIAS
Year:
2019
Document type:
Article
Affiliation country:
Japan