Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau.
Int J Mol Sci
; 20(17)2019 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-31480543
ABSTRACT
Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer's disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD mouse models. Although emerged as a promising target for AD, most of the HDAC inhibitors are poorly selective and could cause unwanted side effects. Here we show that tau is one of the cytosolic substrates of HDAC and the treatment of HDAC inhibitors such as Scriptaid, M344, BML281, and SAHA could increase the level of acetylated tau, resulting in the activation of tau pathology.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tau Proteins
/
Histone Deacetylase Inhibitors
/
Protein Aggregation, Pathological
/
Histone Deacetylases
Limits:
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2019
Document type:
Article