Development of brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer's disease.

Janssen, Bieneke; Mach, Robert H

Janssen, Bieneke; Mach, Robert H.

Affiliation

Janssen B; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: rmach@pennmedicine.upenn.edu.

Prog Mol Biol Transl Sci ; 165: 371-399, 2019.

Article in En | MEDLINE | ID: mdl-31481170

Subject(s)

Alzheimer Disease/diagnostic imaging; Alzheimer Disease/pathology; Brain/diagnostic imaging; Brain/pathology; Inflammation/diagnostic imaging; Inflammation/pathology; Positron-Emission Tomography; Animals; Humans; Radiopharmaceuticals/chemistry; Receptors, GABA/metabolism

Key words

Cannabinoid receptor type 2; Colony stimulating factor 1 receptor; Cyclooxygenase-2; Microglia; Microglial activation; Neuroinflammation; P2X(7) receptor; Positron emission tomography; Reactive oxygen species; Translocator protein 18kDa

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Positron-Emission Tomography / Alzheimer Disease / Inflammation Limits: Animals / Humans Language: En Journal: Prog Mol Biol Transl Sci Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: United States Country of publication: Netherlands

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