Early-Life Environmental Exposures and Blood Pressure in Children.
J Am Coll Cardiol
; 74(10): 1317-1328, 2019 09 10.
Article
in En
| MEDLINE
| ID: mdl-31488269
ABSTRACT
BACKGROUND:
Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously.OBJECTIVES:
This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children.METHODS:
Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously.RESULTS:
Decreases in systolic BP were observed with facility density (ß change for an interquartile-range increase in exposure -1.7 mm Hg [95% confidence interval (CI) -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE -1.6 mm Hg [95% CI -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI -2.4 to -0.6 mm Hg]), and mono-benzyl phthalate (-0.7 mm Hg [95% CI -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI 0.3 to 1.6 mm Hg]).CONCLUSIONS:
This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Environmental Exposure
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Environmental Pollutants
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Hypertension
Type of study:
Diagnostic_studies
Limits:
Child
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Female
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Humans
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Male
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Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
J Am Coll Cardiol
Year:
2019
Document type:
Article
Affiliation country:
Spain
Publication country:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA