Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study.

Crabbé, Melissa; Dirkx, Nina; Casteels, Cindy; Laere, Koen Van

Crabbé, Melissa; Dirkx, Nina; Casteels, Cindy; Laere, Koen Van.

Affiliation

Crabbé M; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium. crabbe.melissa@outlook.com.
Dirkx N; MoSAIC - Molecular Small Animal Imaging Centre, KU Leuven, Leuven, Belgium. crabbe.melissa@outlook.com.
Casteels C; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
Laere KV; MoSAIC - Molecular Small Animal Imaging Centre, KU Leuven, Leuven, Belgium.

Sci Rep ; 9(1): 12916, 2019 09 09.

Article in En | MEDLINE | ID: mdl-31501497

Subject(s)

Excitatory Postsynaptic Potentials; Neurodegenerative Diseases/etiology; Neurodegenerative Diseases/metabolism; Receptor, Metabotropic Glutamate 5/metabolism; Animals; Behavior, Animal; Biomarkers; Cell Survival; Corpus Striatum/metabolism; Corpus Striatum/pathology; Disease Models, Animal; Glutamic Acid/metabolism; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Neurodegenerative Diseases/diagnostic imaging; Neurodegenerative Diseases/pathology; Positron-Emission Tomography; Rats; Receptor, Metabotropic Glutamate 5/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Excitatory Postsynaptic Potentials / Receptor, Metabotropic Glutamate 5 Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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