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In vivo activation of PEGylated long circulating lipid nanoparticle to achieve efficient siRNA delivery and target gene knock down in solid tumors.
Sasayama, Yumi; Hasegawa, Maki; Taguchi, Eri; Kubota, Kohei; Kuboyama, Takeshi; Naoi, Tomoyuki; Yabuuchi, Hayato; Shimai, Norie; Asano, Miyoko; Tokunaga, Akihiro; Ishii, Toshihiko; Enokizono, Junichi.
Affiliation
  • Sasayama Y; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Hasegawa M; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Taguchi E; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Kubota K; CMC R&D Center, Production Division, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Kuboyama T; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan; CMC R&D Center, Production Division, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Naoi T; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Yabuuchi H; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Shimai N; CMC R&D Center, Production Division, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Asano M; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Tokunaga A; Oncology Research Laboratories, Oncology R&D unit, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Ishii T; Oncology Research Laboratories, Oncology R&D unit, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Enokizono J; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan. Electronic address: junichi.enokizono.vj@kyowakirin.com.
J Control Release ; 311-312: 245-256, 2019 10.
Article in En | MEDLINE | ID: mdl-31505222
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylethanolamines / Polyethylene Glycols / Proto-Oncogene Proteins p21(ras) / RNA, Small Interfering / Nanoparticles / Neoplasms Limits: Animals / Humans / Male Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Japan Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylethanolamines / Polyethylene Glycols / Proto-Oncogene Proteins p21(ras) / RNA, Small Interfering / Nanoparticles / Neoplasms Limits: Animals / Humans / Male Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Japan Country of publication: Netherlands