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Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice.
Choi, Jae-Hoon; Matsuzaki, Nobuo; Wu, Jing; Kotajima, Mihaya; Hirai, Hirofumi; Kondo, Mitsuru; Asakawa, Tomohiro; Inai, Makoto; Ouchi, Hitoshi; Kan, Toshiyuki; Kawagishi, Hirokazu.
Affiliation
  • Choi JH; Graduate School of Integrated Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Matsuzaki N; Research Institute of Green Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Wu J; Graduate School of Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Kotajima M; Research Institute of Green Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Hirai H; Graduate School of Integrated Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Kondo M; Graduate School of Integrated Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Asakawa T; Research Institute of Green Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Inai M; Research Institute of Green Science and Technology , Shizuoka University , 836 Ohya , Suruga-ku, Shizuoka 422-8529 , Japan.
  • Ouchi H; Tokai University Institute of Innovative Science and Technology , 4-1-1 Kitakaname , Hiratsuka City , Kanagawa 259-1292 , Japan.
  • Kan T; School of Pharmaceutical Sciences , University of Shizuoka , 52-1 Yada , Suruga-ku, Shizuoka 422-8526 , Japan.
  • Kawagishi H; School of Pharmaceutical Sciences , University of Shizuoka , 52-1 Yada , Suruga-ku, Shizuoka 422-8526 , Japan.
Org Lett ; 21(19): 7841-7845, 2019 10 04.
Article in En | MEDLINE | ID: mdl-31518147
ABSTRACT
The metabolism of imidazole-4-carboxamide (ICA) in plants has been unknown. Two metabolites (1 and 2) were isolated from ICA-treated rice, and their structures were determined by spectroscopic analysis including the single-crystal X-ray diffraction technique and synthesis. The ribotide of ICA (3), whose existence was predicted, was also synthesized and detected from the treated rice by LC-MS/MS. These results indicated that rice might interconvert ICA, 1, and 3 to regulate the biological activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribonucleosides / Ribonucleotides / Oryza / Aminoimidazole Carboxamide Type of study: Prognostic_studies Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribonucleosides / Ribonucleotides / Oryza / Aminoimidazole Carboxamide Type of study: Prognostic_studies Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: Japan