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Synthesis of the EFG Framework of Tamulamides A and B.
Kelley, Elizabeth H; Jamison, Timothy F.
Affiliation
  • Kelley EH; Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
  • Jamison TF; Department of Chemistry , Massachusetts Institute of Technology , 77 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.
Org Lett ; 21(19): 8027-8030, 2019 10 04.
Article in En | MEDLINE | ID: mdl-31523969
ABSTRACT
Synthesis of the fused polycyclic ether motif comprising the EFG rings of the marine ladder polyethers tamulamides A and B has been achieved via two different etherification strategies. Ultimately, a reductive etherification approach proved most successful due to tolerance of the G ring substitution and provided the EFG 6,7,6 ring system in 58% yield.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxocins / Marine Toxins Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxocins / Marine Toxins Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: United States