Your browser doesn't support javascript.
loading
Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient.
Contreras, Deisy A; Fitzwater, Sean P; Nanayakkara, Deepa D; Schaenman, Joanna; Aldrovandi, Grace M; Garner, Omai B; Yang, Shangxin.
Affiliation
  • Contreras DA; Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, USA.
  • Fitzwater SP; Division of Pediatric Infectious Diseases, UCLA Mattel Children's Hospital, Los Angeles, California, USA.
  • Nanayakkara DD; Division of Infectious Diseases, UCLA Medical Center, Los Angeles, California, USA.
  • Schaenman J; Division of Infectious Diseases, UCLA Medical Center, Los Angeles, California, USA.
  • Aldrovandi GM; Division of Pediatric Infectious Diseases, UCLA Mattel Children's Hospital, Los Angeles, California, USA.
  • Garner OB; Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, USA.
  • Yang S; Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, USA ShangxinYang@mednet.ucla.edu.
Antimicrob Agents Chemother ; 64(4)2020 03 24.
Article in En | MEDLINE | ID: mdl-31527031
ABSTRACT
We report here a fatal case of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in a renal transplant patient without a travel history in the prior year, from whom 2 genetically different CRKP (sequence type 14 [ST14] and ST2497) strains carrying the same plasmids and antimicrobial resistance genes, including blaNDM-1, blaOXA-232, blaCTX-M-15, armA, and tet(D), were isolated from blood and the abdominal cavity. The isolates were susceptible to colistin, tigecycline, eravacycline, and cefiderocol, which was used to treat the CRKP in combination with ceftazidime-avibactam and polymyxin B and resulted in bacterial clearance. Despite the aggressive treatment, the patient died of ischemic colitis and multiorgan failure.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Klebsiella Infections / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Aged / Female / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2020 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Klebsiella Infections / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Aged / Female / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2020 Document type: Article Affiliation country: United States