Connectivity between the anterior insula and dorsolateral prefrontal cortex links early symptom improvement to treatment response.
J Affect Disord
; 260: 490-497, 2020 01 01.
Article
in En
| MEDLINE
| ID: mdl-31539685
ABSTRACT
BACKGROUND:
Early improvement (EI) following treatment with antidepressants is a widely reported predictor to the treatment response. This study aimed to identify the resting-state functional connectivity (rs-FC) and its related clinical features that link the treatment response at the time of EI.METHODS:
This study included 23 first-episode treatment-naive patients with MDD. After 2 weeks of antidepressant treatment, these patients received 3.0 Tesla resting-state functional magnetic resonance imaging scanning and were subgrouped into an EI group (Nâ¯=â¯13) and a non-EI group (Nâ¯=â¯10). Using the anterior insula (rAI) as a seed region, this study identified the rs-FC that were associated with both EI and the treatment response at week 12, and further tested the associations of the identified rs-FC with either the clinical features or the early symptom improvement.RESULTS:
Rs-FC between rAI and the left dorsolateral prefrontal cortex (dlPFC) was associated with EI (t21â¯=â¯-6.091, pâ¯=â¯0.022 after FDR correction for multiple comparisons). This rs-FC was also associated with an interaction between EI and the treatment response at the week 12 (t21â¯=â¯-5.361, pâ¯=â¯6.37e-5). Moreover, among the clinical features, this rs-FC was associated with the early symptom improvement in the insomnia, somatic symptoms, and anxiety symptoms, and these early symptom improvements were associated with the treatment response.CONCLUSION:
Rs-FC between the rAI and the left dlPFC played a crucial role in the early antidepressant effect, which linked the treatment response. The early treatment effect relating to rAI may represent an early symptom improvement in self-perceptual anxiety, somatic symptoms and insomnia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebral Cortex
/
Prefrontal Cortex
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Depressive Disorder, Major
/
Antidepressive Agents
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Affect Disord
Year:
2020
Document type:
Article
Affiliation country:
China