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A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.
George, Sally L; Izquierdo, Elisa; Campbell, James; Koutroumanidou, Eleni; Proszek, Paula; Jamal, Sabri; Hughes, Deborah; Yuan, Lina; Marshall, Lynley V; Carceller, Fernando; Chisholm, Julia C; Vaidya, Sucheta; Mandeville, Henry; Angelini, Paola; Wasti, Ajla; Bexelius, Tomas; Thway, Khin; Gatz, Susanne A; Clarke, Matthew; Al-Lazikani, Bissan; Barone, Giuseppe; Anderson, John; Tweddle, Deborah A; Gonzalez, David; Walker, Brian A; Barton, Jack; Depani, Sarita; Eze, Jessica; Ahmed, Saira W; Moreno, Lucas; Pearson, Andrew; Shipley, Janet; Jones, Chris; Hargrave, Darren; Jacques, Thomas S; Hubank, Michael; Chesler, Louis.
Affiliation
  • George SL; Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK. Electronic address: sally.george@icr.ac.uk.
  • Izquierdo E; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK; Glioma Team, Division of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, UK.
  • Campbell J; Bioinformatics Core Facility, The Institute of Cancer Research, London, UK.
  • Koutroumanidou E; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK.
  • Proszek P; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK.
  • Jamal S; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK.
  • Hughes D; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK.
  • Yuan L; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK.
  • Marshall LV; Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Carceller F; Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Chisholm JC; Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Vaidya S; Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Mandeville H; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Angelini P; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Wasti A; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Bexelius T; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Thway K; Pathology Department, Royal Marsden NHS Foundation Trust, London, UK.
  • Gatz SA; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK; Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, UK; Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Science
  • Clarke M; Glioma Team, Division of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, UK.
  • Al-Lazikani B; Bioinformatics Core Facility, The Institute of Cancer Research, London, UK.
  • Barone G; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Anderson J; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.
  • Tweddle DA; Northern Institute for Cancer Research, Newcastle University, Newcastle, UK.
  • Gonzalez D; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK.
  • Walker BA; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Barton J; Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.
  • Depani S; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Eze J; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Department of Histology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Ahmed SW; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Department of Histology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Moreno L; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK; HNJ-CNIO Clinical Research Unit, Hospital Universitario Nino Jesus, Madrid, Spain; Paediatric Oncology & Haematology, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Pearson A; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
  • Shipley J; Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, UK.
  • Jones C; Glioma Team, Division of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, UK.
  • Hargrave D; Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Jacques TS; Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Department of Histology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Hubank M; Molecular Diagnostics Department, The Institute of Cancer Research and Clinical Genomics, The Royal Marsden NHS Foundation, London, UK.
  • Chesler L; Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK.
Eur J Cancer ; 121: 224-235, 2019 11.
Article in En | MEDLINE | ID: mdl-31543384
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Neoplasm / Gene Expression Profiling / Precision Medicine / High-Throughput Nucleotide Sequencing / Transcriptome / Circulating Tumor DNA Type of study: Diagnostic_studies / Evaluation_studies / Prognostic_studies Aspects: Implementation_research Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Eur J Cancer Year: 2019 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Neoplasm / Gene Expression Profiling / Precision Medicine / High-Throughput Nucleotide Sequencing / Transcriptome / Circulating Tumor DNA Type of study: Diagnostic_studies / Evaluation_studies / Prognostic_studies Aspects: Implementation_research Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Eur J Cancer Year: 2019 Document type: Article Country of publication: United kingdom