Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T­cell lymphoma expressing the ITK­SYK fusion gene.

Zhang, Lei-Lei; Pan, Hua-Xiong; Wang, Yi-Xuan; Guo, Tao; Liu, Lin

Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral Tcell lymphoma expressing the ITKSYK fusion gene.

Zhang, Lei-Lei; Pan, Hua-Xiong; Wang, Yi-Xuan; Guo, Tao; Liu, Lin.

Affiliation

Zhang LL; Department of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Pan HX; Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Wang YX; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Guo T; Department of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Liu L; Department of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Int J Oncol ; 55(5): 1077-1089, 2019 Nov.

Article in En | MEDLINE | ID: mdl-31545408

Subject(s)

Biomarkers, Tumor/metabolism; Gene Expression Regulation, Neoplastic; Interleukin Receptor Common gamma Subunit/metabolism; Janus Kinase 3/metabolism; Lymphoma, T-Cell, Peripheral/pathology; Oncogene Proteins, Fusion/metabolism; STAT5 Transcription Factor/metabolism; Tumor Suppressor Proteins/metabolism; Animals; Apoptosis; Biomarkers, Tumor/genetics; Cell Proliferation; Female; Gene Expression Profiling; Genome, Human; Humans; Interleukin Receptor Common gamma Subunit/genetics; Janus Kinase 3/genetics; Lymphoma, T-Cell, Peripheral/drug therapy; Lymphoma, T-Cell, Peripheral/genetics; Lymphoma, T-Cell, Peripheral/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Oncogene Proteins, Fusion/genetics; Protein Kinase Inhibitors/pharmacology; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; STAT5 Transcription Factor/genetics; Syk Kinase/genetics; Syk Kinase/metabolism; Tumor Cells, Cultured; Tumor Suppressor Proteins/genetics; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Gene Expression Regulation, Neoplastic / Oncogene Proteins, Fusion / Lymphoma, T-Cell, Peripheral / Tumor Suppressor Proteins / STAT5 Transcription Factor / Janus Kinase 3 / Interleukin Receptor Common gamma Subunit Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2019 Document type: Article Country of publication: Greece

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