A Prolonged Treatment Response in Acquired Von Willebrand Syndrome.
Hamostaseologie
; 39(4): 409-412, 2019 Nov.
Article
in En
| MEDLINE
| ID: mdl-31546261
ABSTRACT
Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder. We report herein a case of AVWS due to a monoclonal gammopathy of undetermined significance, in which a transient but prolonged response to a treatment by intravenous immunoglobulin (IVIG) was observed. The diagnosis was fortuitously made in a preoperative setting for neurosurgery, after biological exploration of an isolated prolonged activated partial thromboplastin time. AVWS was confirmed by an accelerated clearance of an infused plasma-derived von Willebrand factor (VWF) concentrate. High doses of IVIG were used to perform the neurosurgery. Fifty-four days after IVIG, the patient was still responding to treatment with normal levels of factor VIII and VWF.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Von Willebrand Diseases
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Hamostaseologie
Year:
2019
Document type:
Article
Affiliation country:
France