Lack of response to treatment with levetiracetam in extreme preterm infants with seizures.
J Perinatol
; 39(11): 1480-1484, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31548579
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the effectiveness of monotherapy with levetiracetam (LEV) in achieving seizure cessation in a retrospective cohort of extreme preterm infants with seizures. STUDYDESIGN:
Charts of infants with a diagnosis of neonatal seizures admitted to the NICU between 2013 and 2017 were reviewed. Seizures were diagnosed using continuous video electroencephalography. All infants were initially started on LEV and reached a dose of 80 mg/kg/day. Other ASMs were added to LEV if seizures continued after 2 days. Data on additional clinical variables were collected for each infant.RESULT:
Sixty-one infants born <28 weeks of gestation met inclusion criteria. Seventy-four percent of patients did not respond to LEV monotherapy and required additional medications.CONCLUSIONS:
LEV monotherapy stopped seizures in only a small portion of cases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seizures
/
Levetiracetam
/
Anticonvulsants
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2019
Document type:
Article
Affiliation country:
United States