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Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitors.
Guazzelli, Lorenzo; D'Andrea, Felicia; Sartini, Stefania; Giorgelli, Francesco; Confini, Gianluca; Quattrini, Luca; Piano, Ilaria; Nencetti, Susanna; Orlandini, Elisabetta; Gargini, Claudia; La Motta, Concettina.
Affiliation
  • Guazzelli L; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • D'Andrea F; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy. Electronic address: felicia.dandrea@unipi.it.
  • Sartini S; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • Giorgelli F; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • Confini G; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • Quattrini L; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • Piano I; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • Nencetti S; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • Orlandini E; Department of Earth Sciences, University of Pisa, Via Santa Maria 53, 56126 Pisa, Italy; Research Center "E. Piaggio", University of Pisa, Pisa, 56122, Italy.
  • Gargini C; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy.
  • La Motta C; Department of Pharmacy, University of Pisa, Via Bonanno 6/33, 56126 Pisa, Italy. Electronic address: concettina.lamotta@unipi.it.
Bioorg Chem ; 92: 103298, 2019 11.
Article in En | MEDLINE | ID: mdl-31557624
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Aldehyde Reductase / Enzyme Inhibitors / Alpha-Glucosidases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Document type: Article Affiliation country: Italy Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Aldehyde Reductase / Enzyme Inhibitors / Alpha-Glucosidases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Document type: Article Affiliation country: Italy Country of publication: United States