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GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis.
Hu, Po; Li, Hui; Yu, Xiaoxuan; Liu, Xiao; Wang, Xiangyuan; Qing, Yingjie; Wang, Zhanyu; Wang, Hongzheng; Zhu, Mengyuan; Xu, Jingyan; Tan, Renxiang; Guo, Qinglong; Hui, Hui.
Affiliation
  • Hu P; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Li H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Yu X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Liu X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Wang X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Qing Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Wang Z; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Wang H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Zhu M; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
  • Xu J; Department of Hematology, The Affiliated DrumTower Hospital of Nanjing University Medical School, Nanjing, 210008, People's Republic of China.
  • Tan R; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, People's Republic of China.
  • Guo Q; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address: anticancer_drug@163.com.
  • Hui H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address: moyehh@163.com.
Free Radic Biol Med ; 145: 237-249, 2019 12.
Article in En | MEDLINE | ID: mdl-31560953
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Proto-Oncogene Proteins c-akt / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Bcl-2-Like Protein 11 / Forkhead Box Protein O3 Limits: Animals / Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2019 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Proto-Oncogene Proteins c-akt / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Bcl-2-Like Protein 11 / Forkhead Box Protein O3 Limits: Animals / Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2019 Document type: Article Country of publication: United States