Targeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti-PD-1 Resistance in Head and Neck Cancer.

Zhou, Liye; Mudianto, Tenny; Ma, Xiaojing; Riley, Rachel; Uppaluri, Ravindra

Zhou, Liye; Mudianto, Tenny; Ma, Xiaojing; Riley, Rachel; Uppaluri, Ravindra.

Affiliation

Zhou L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Mudianto T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Ma X; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Riley R; School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, China.
Uppaluri R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Clin Cancer Res ; 26(1): 290-300, 2020 01 01.

Article in En | MEDLINE | ID: mdl-31562203

Subject(s)

Antigen Presentation; Benzamides/pharmacology; Drug Resistance, Neoplasm/drug effects; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors; Head and Neck Neoplasms/immunology; Immunity, Cellular; Indoles/pharmacology; Pyridones/pharmacology; Animals; Antineoplastic Agents, Immunological/pharmacology; Biphenyl Compounds; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Head and Neck Neoplasms/drug therapy; Head and Neck Neoplasms/metabolism; Humans; Mice; Mice, Inbred C57BL; Morpholines; Programmed Cell Death 1 Receptor/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Benzamides / Antigen Presentation / Drug Resistance, Neoplasm / Enhancer of Zeste Homolog 2 Protein / Head and Neck Neoplasms / Immunity, Cellular / Indoles Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2020 Document type: Article Country of publication: United States

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