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Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling.
Chokshi, Varun; Gao, Ming; Grier, Bryce D; Owens, Ashley; Wang, Hui; Worley, Paul F; Lee, Hey-Kyoung.
Affiliation
  • Chokshi V; The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Cell Molecular Developmental Biology and Biophysics (CMDB) Graduate Program, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Gao M; The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Grier BD; The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Owens A; The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Wang H; The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Worley PF; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Lee HK; The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Cell Molecular Developmental Biology and Biophysics (CMDB) Graduate Program, Johns Hopkins University, Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medi
Neuron ; 104(4): 736-748.e6, 2019 11 20.
Article in En | MEDLINE | ID: mdl-31563294
ABSTRACT
Effective sensory processing depends on sensory experience-dependent metaplasticity, which allows homeostatic maintenance of neural network activity and preserves feature selectivity. Following a strong increase in sensory drive, plasticity mechanisms that decrease the strength of excitatory synapses are preferentially engaged to maintain stability in neural networks. Such adaptation has been demonstrated in various model systems, including mouse primary visual cortex (V1), where excitatory synapses on layer 2/3 (L2/3) neurons undergo rapid reduction in strength when visually deprived mice are reexposed to light. Here, we report that this form of plasticity is specific to intracortical inputs to V1 L2/3 neurons and depends on the activity of NMDA receptors (NMDARs) and group I metabotropic glutamate receptor 5 (mGluR5). Furthermore, we found that expression of the immediate early gene (IEG) Homer1a (H1a) and its subsequent interaction with mGluR5s are necessary for this input-specific metaplasticity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Visual Cortex / Signal Transduction / Receptor, Metabotropic Glutamate 5 / Homer Scaffolding Proteins / Neuronal Plasticity Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Visual Cortex / Signal Transduction / Receptor, Metabotropic Glutamate 5 / Homer Scaffolding Proteins / Neuronal Plasticity Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country: United States