Strength of the human mixed lymphocyte reaction (MLR) and its suppression by azathioprine or 6-mercaptopurine.
Br J Clin Pharmacol
; 19(1): 105-7, 1985 Jan.
Article
in En
| MEDLINE
| ID: mdl-3156615
ABSTRACT
Azathioprine (36 microM) had a significantly (P less than 0.00003) greater inhibitory effect on human MLR responses below 20,000 counts/min than on responses above 20,000 counts/min. In contrast, 6-mercaptopurine (100 microM) had a similar suppressive effect on MLR responses below and above 20,000 counts/min suggesting it has a different mode of action to azathioprine.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Azathioprine
/
Graft Survival
/
Mercaptopurine
Limits:
Humans
Language:
En
Journal:
Br J Clin Pharmacol
Year:
1985
Document type:
Article