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AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.
Sala, Laura; Chandrasekhar, Srividya; Vidigal, Joana A.
Affiliation
  • Sala L; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
  • Chandrasekhar S; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
  • Vidigal JA; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA, joana.vidigal@nih.gov.
Front Biosci (Landmark Ed) ; 25(1): 1-42, 2020 01 01.
Article in En | MEDLINE | ID: mdl-31585876
ABSTRACT
Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Multigene Family / MicroRNAs / RNA, Small Interfering / Argonaute Proteins Limits: Animals / Humans Language: En Journal: Front Biosci (Landmark Ed) Year: 2020 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Multigene Family / MicroRNAs / RNA, Small Interfering / Argonaute Proteins Limits: Animals / Humans Language: En Journal: Front Biosci (Landmark Ed) Year: 2020 Document type: Article Affiliation country: United States