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Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19.
Asnani, Mukta; Hayer, Katharina E; Naqvi, Ammar S; Zheng, Sisi; Yang, Scarlett Y; Oldridge, Derek; Ibrahim, Fadia; Maragkakis, Manolis; Gazzara, Matthew R; Black, Kathryn L; Bagashev, Asen; Taylor, Deanne; Mourelatos, Zissimos; Grupp, Stephan A; Barrett, David; Maris, John M; Sotillo, Elena; Barash, Yoseph; Thomas-Tikhonenko, Andrei.
Affiliation
  • Asnani M; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Hayer KE; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Naqvi AS; DBHi Bioinformatics Group, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Zheng S; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Yang SY; DBHi Bioinformatics Group, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Oldridge D; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Ibrahim F; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Maragkakis M; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Gazzara MR; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Black KL; Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Bagashev A; Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Taylor D; Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Mourelatos Z; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA.
  • Grupp SA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Barrett D; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Maris JM; Lonza Biologics, Portsmouth, NH, USA.
  • Sotillo E; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Barash Y; DBHi Bioinformatics Group, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Thomas-Tikhonenko A; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Leukemia ; 34(4): 1202-1207, 2020 04.
Article in En | MEDLINE | ID: mdl-31591467
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Introns / Leukemia / Frameshift Mutation / Immunotherapy, Adoptive / Antigens, CD19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Introns / Leukemia / Frameshift Mutation / Immunotherapy, Adoptive / Antigens, CD19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom