Silver-Catalyzed Decarboxylative Alkylfluorination of Alkenes.
Org Lett
; 21(20): 8496-8500, 2019 10 18.
Article
in En
| MEDLINE
| ID: mdl-31591887
ABSTRACT
A decarboxylation of alkyl carboxylic acids for alkylfluorination of alkene was developed, with the catalysis of silver(I) and Selectfluor as both the oxidant and fluorine source. This reaction is highly chemoselective, producing the decarboxylative alkylfluorination products rather than the competitive fluorination of aliphatic carboxylic acids. This practical transformation proceeds efficiently in aqueous media at room temperature and exhibits a large range of functional-group tolerance in various primary and secondary aliphatic carboxylates and alkenes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2019
Document type:
Article